I travel to Chicago (and elsewhere) on a regular basis and the House of Blues Hotel is the best downtown hotel I have ever stayed at..bar none.
The staff is very friendly and accommodating and I have never had a problem that was not resolved immediately. The hotel is walking distance from excellent food and world class shopping on Michigan avenue. Across the driveway from the hotel is the House of Blue Restaraunt and music venue where you can see top musicians nightly.
I am not easially impressed. I have traveled all over the world. This hotel is totally cool!